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Welcome to the Clinical Trials Office 

As you consider treatment options for yourself or your loved one, you may consider participation in a clinical trial. The resources below provide general and specific information that can help you navigate the clinical trial process.

Current Clinical Trials

Below is a list of enrolling clinical trials at MaineHealth.  Studies can open and close quickly so please contact the Clinical Trials Office directly or speak with your healthcare professional if you are interested in learning more about one of the trials.  You can reach the Clinical Trials Office at 207-396-8670 or email at clinicalresearch@mmc.org.  The following list was updated on 7.24.19, and is provided here on a monthly basis.

For a complete list of trials open in the U.S. and abroad, visit www.clinicaltrials.gov.

(MOST) Prospective, Longitudinal, Non-Interventional Study Of Disease Burden And Treatment Of Patients With Low-Risk Myelofibrosis (MF) Or High-Risk Essential Thrombocythemia (ET) Or ET Patients Receiving ET-Directed Therapy  Learn more

(A011401) Randomized Phase III Trial Evaluating The Role Of Weight Loss In Adjuvant Treatment Of Overweight And Obese Women With Early Breast Cancer (BWEL)  Learn more

(A011502) A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for HER2 Negative Breast Cancer: The ABC Trial Learn more

(ASPIRE) A Phase II Multi-institutional Study of Concurrent Radiotherapy, Palbociclib, and Hormone Therapy for Treatment of Bone Metastasis in Breast Cancer Patients (Winship 4472-18) Learn more

(BR002) A Phase IIR/III Trial of Standard of Care with or without Stereotactic Body Radiotherapy (SBRT) and/or Surgical Ablation for Newly Oligometastatic Breast Cancer Learn more

(BR003) A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer Learn more

(BR004) A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab With Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer Learn more

(CCTG MA.39) TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer Learn more

(FABREC) Study of Radiation Fractionation on Patient Outcomes After Breast REConstruction (FABREC) for Invasive Breast Carcinoma Learn more

(NOHA in BRCA) A Pilot Study of NOHA levels in BRCA positive Breast Cancer

(NOHA in TNBC) A Pilot Study of NOHA as a monitoring biomarker in triple negative breast cancer (TNBC)

(ODO-TE-B301) A Multinational, Multicenter, Randomized, Phase 3 Study of Tesetaxel plus a Reduced Dose of Capecitabine versus Capecitabine Alone in Patients with HER2 Negative, Hormone Receptor Positive, Locally Advanced or Metastatic Breast Cancer Previously Treated with a Taxane Learn more

(RTOG 1304/ NSABP B-51) A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy Learn more

(S1418) A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer With = 1 CM Residual Invasive Cancer or Positive Lymph Nodes (ypN+) After Neoadjuvant Chemotherapy Learn more

(AALL1331) Risk-Stratified Randomized Phase III Testing of Blinatumomab (NSC#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL)
Learn more

(AALL1631) International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Testing Imatinib in Combination With Two Different Cytotoxic Chemotherapy Backbones Learn more

(AALL1731) A Phase 3 Trial Investigating Blinatumomab ( NSC# 765986) in Combination With Chemotherapy in Patients With Newly Diagnosed Standard Risk or Down Syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients With Localized B-Lymphoblastic Lymphoma (B-LLy) Learn more

(ACNS1422) A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients Learn more

(AGCT1531) A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Learn more

(AHEP1531) Pediatric Hepatic Malignancy International Therapeutic Trial (PHITT) Learn more

(ALTE11C2) Health Effects After Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy Learn more

(ANBL00B1) Neuroblastoma Biology Studies Learn more

(ANBL1232) Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients With Non-High-Risk Neuroblastoma Learn more

(ANBL1531) A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children With Newly Diagnosed High-Risk Neuroblastoma (NBL) Learn more

(APEC14B1) Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study Learn more

(APEC1621C) NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)- Phase 2 Subprotocol of Tazemetostat in Patients With Tumors Harboring Alterations in EZH2 or Members of the SWI/SNF Complex Learn more

(AREN03B2) Renal Tumors Classification, Biology, and Banking Study Learn more

(ARST1431) A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating With Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864) in Patients With Intermediate Risk (IR) Rhabdomyosarcoma (RMS) Learn more

(COG AALL1521)  A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia Learn more

(COG NCI Pediatric MATCH) COG Pediatric Molecular Analysis for Therapy Choice Screening Protocol Learn more

(NEPA-15-31) A multicenter, multinational, randomized, double-blind, pharmacokinetic and pharmacodynamic (PK/PD) dose-finding study of oral netupitant administered concomitantly with oral palonosetron in pediatric cancer patients for the prevention of nausea and vomiting associated with emetogenic chemotherapy Learn more

(SJ HOD08)  Reduced Duration Stanford V Chemotherapy with or without Low-Dose Tailored-Field Radiation Therapy for Favorable Risk Pediatric Hodgkin Lymphoma Learn more

(GI002) Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer Learn more

(A021502) Randomized Trial of Standard Chemotherapy Alone or Combined With Atezolizumab as Adjuvant Therapy for Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair Learn more

(GI004) Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy With or Without Atezolizumab or Atezolizumab Monotherapy in the First-Line Treatment of Patients With Deficient DNA Mismatch Repair (dMMR) Metastatic Colorectal Cancer Learn more

(S1815) A Phase III Randomized Trial of Gemcitabine, Cisplatin, and Nab-Paclitaxel Versus Gemcitabine and Cisplatin in Newly Diagnosed, Advanced Biliary Tract Cancers Learn more

(A031501) Phase III Randomized Adjuvant Study of MK-3475 (Pembrolizumab) in Muscle Invasive and Locally Advanced Urothelial Carcinoma (AMBASSADOR) Versus Observation Learn more

(EA8143) A Phase 3 Randomized Study Comparing Perioperative Nivolumab vs. Observation in Patients With Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC) Learn more

(EA8153) Cabazitaxel With Abiraterone Versus Abiraterone Alone Randomized Trial for Extensive Disease Following Docetaxel: The CHAARTED2 Trial Learn more

(GU005) Phase III IGRT and SBRT vs IGRT and Hypofractionated IMRT for Localized Intermediate Risk Prostate Cancer Learn more

(GU006) Radiation Therapy With or Without Apalutamide in Treating Patients With Stage III-IV Prostate Cancer Learn more

(S1802) Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer Learn more

(S1806) Phase III Randomized Trial of Concurrent Chemoradiotherapy With or Without Atezolizumab in Localized Muscle Invasive Bladder Cancer Learn more

(STEEL) A Trial to See What the Results Are for Radiation Therapy and Hormone Therapy vs Radiation Therapy With Enhanced Hormone Therapy With Enzalutamide for Patients With PSA Recurrence After Surgery (STEEL) Learn more

(FIRST 3000-03-005)  ENGOT-0V44 The FIRST (First-line Ovarian Cancer Treatment With Niraparib Plus TSR-042) Study: A Randomized, Double-Blind, Phase 3 Comparison of Platinum-Based Therapy With TSR-042 and Niraparib Versus Standard of Care Platinum-Based Therapy as First-Line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer Learn more

(GOG 0237)  Comparative Analysis of CA-IX, p16, Proliferative Markers, and Human Papilloma Virus (HPV) in the Diagnosis of Significant Cervical Lesions in Patients With a Cytologic Diagnosis of Atypical Glandular Cells (AGC) Learn more

(GOG 0238) A Randomized Trial of Pelvic Irradiation With or Without Concurrent Weekly Cisplatin in Patients With Pelvic-Only Recurrence of Carcinoma of the Uterine Corpus Learn more

(GOG 3020 ATHENA) A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy Learn more

(GY005) A Randomized Phase II/III Study of the Combination of Cediranib and Olaparib Compared to Cediranib or Olaparib Alone, or Standard of Care Chemotherapy in Women with Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (COCOS) Learn more

(GY012) A Randomized Phase II Study Comparing Single-Agent Olaparib, Single Agent Cediranib, and the Combination of Cediranib/Olaparib in Women with Recurrent, Persistent or Metastatic Endometrial Cancer Learn more

(MATCH) EAY-131:  Molecular Analysis for Therapy Choice (MATCH) Learn more

(RTOG 1171/ GOG 0263) A Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated with Initial Radical Hysterectomy and Pelvic Lymphadenectomy Learn more

(TSR-042) A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-042, an Anti-PD-1 Monoclonal Antibody, in Patients With Advanced Solid Tumors Learn more

(S1616) A Phase II Randomized Study of Nivolumab (NSC-748726) With Ipilimumab (NSC-732442) or Ipilimumab Alone in Advanced Melanoma Patients Refractory to an Anti-PD1 or Anti-PD-L1 Agent Learn more

(BN003)  Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma Learn more

(BN005) A Phase II Randomized Trial of Proton Vs. Photon Therapy (IMRT) for Cognitive Preservation in Patients With IDH Mutant, Low to Intermediate Grade Gliomas Learn more

(ChemoID Assay) Standard Chemotherapy Versus Chemotherapy Chosen by Cancer Stem Cell Chemosensitivity Testing in the Management of Patients With Recurrent Glioblastoma Multiforme (GBM). Learn more

(MCGI)  The Maine Cancer Genomics Initiative (MCGI):  A Study of Oncology Clinician and Patient Experiences with Clinical Genomics in Maine (051817v1)

(S1612) A Randomized Phase II/III Trial of “Novel Therapeutics” Versus Azacitidine in Newly Diagnosed Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS), Age 60 or Older LEAP: Less-Intense AML Platform Trial Learn more

(S1702)  A Phase II Study of Isatuximab (SAR650984) (NSC-795145) for patients with previously treated AL AMYLOIDOSIS Learn more

(A081105) Randomized Study Of Erlotinib Vs Observation In Patients With Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung Cancer (NSCLC) Learn more

(A151216) Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST) Learn more

(CASTL) Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites Learn more

(E4512) A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein Learn more

(EA5142)  Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) – A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers Learn more

(EAY131-A) MATCH Treatment Subprotocol A: Phase II Trial of Afatinib in Patients with Solid Tumors (Other Than Small Cell and Non-Small Cell Lung Cancer) or Lymphomas, That Have Activating Mutations of EGFR and Have Progressed After Standard Treatment Learn more

(LUNGMAP) A Master Protocol to Evaluate Biomarker-Driven Therapies and Immunotherapies in Previously-Treated Non-Small Cell Lung Cancer (Lung-MAP Screening Study) Learn more

(LUNGMAP-S1900A) A Phase II Study Of Rucaparib In Patients With Genomic LOH HIGH And/Or Deleterious BRCA1/2 Mutation Stage IV Or Recurrent Non-Small Cell Lung Cancer (LUNGMAP Sub-Study) Learn more

(PACIFIC-4)  A Phase III, Randomized, Placebo-controlled, Double-blind, Multi-center, International Study of Durvalumab Following Stereotactic Body Radiation Therapy (SBRT) for the Treatment of Patients With Unresected Stage I/II, Lymph-node Negative Non-small Cell Lung Cancer (PACIFIC-4/RTOG-3515) Learn more

(BELIEVE) Behavior of valve Leaflets and the Incidence of reduced mobility post-surgical aortic valve implant Learn more

(Cardiometabolic Study) Molecular Assessment of Human Cardiometabolic Disease

(Mediterranean Diet) A Comparison Of Mediterranean Diet Vs. Standard Diet In CABG Patients On The Cardiac Cell Signaling And Composition Of Lipid Content Learn more

(ON-X 17mm Valve) ON-X® PROSTHETIC HEART VALVE 17mm AORTIC 23mm MITRAL Learn more

(REFRESH II) Cytosorb® Reduction Of Free Hemoglobin/Acute Kidney Injury (AKI) During Cardiac Surgery Learn more

(SIRT-CVS)  Short Interval Resveratrol in Cardiovascular Surgery (SIRT-CVS) Trial

(ABSORB) A Clinical Evaluation of Absorb BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Lesions Learn more

(AEGIS II) A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome Learn more

(ARTESiA) Apixaban for the Reduction of Thrombo-Embolism in Patients with Device-Detected Sub-Clinical Atrial Fibrillation Learn more

(ASAP TOO) Assessment of the WATCHMAN Device in Patients Unsuitable for Oral Anticoagulation Learn more

(CARILLON)  Assessment of the CARILLON® Mitral Contour System® in Treating Functional Mitral Regurgitation Associated with Heart Failure Learn more

(DAL-GENE) A Phase III, Double-blind, Randomized Placebo-controlled Study to Evaluate the Effects of Dalcetrapib on Cardiovascular (CV) Risk in a Genetically Defined Population With a Recent Acute Coronary Syndrome (ACS): The Dal-GenE Trial Learn more

(EARLY TAVR) Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients with AsYmptomatic Severe Aortic Stenosis: EARLY TAVR trial Learn more

(ECLIPSE) Evaluation of Treatment Strategies for Severe Calcific Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting Stents Learn more

(ENVISAGE) Clinical Study Protocol Edoxaban Versus Standard Of Care And Their Effects On Clinical Outcomes In Patients Having Undergone Transcatheter Aortic Valve Implantation – In Atrial Fibrillation Edoxaban (DU-176B-C-U4001) ENVISAGE-TAVIAF Learn more

(GALACTIC HF) A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects With Chronic Heart Failure With Reduced Ejection Fraction Learn more

(HEART FID) A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Injectafer® (Ferric Carboxymaltose) as Treatment for Heart Failure With Iron Deficiency Learn more

(OPTIMIZE) The OPTIMIZE Trial to Assess the Procedural and Clinical Value of the Svelte IDS and RX Sirolimus-Eluting Coronary Stent Systems for the Treatment of Atherosclerotic Lesions in a Randomized Study Learn more

(PERSPECTIVE) A multicenter, randomized, double-blind, active-controlled study to evaluate the effects of LCZ696 compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction Learn more

(TRILOGY / CaPre) A Phase 3, multi-center, placebo-controlled, randomized, double-blind 26-week study to assess the safety and efficacy of CaPre® in patients with severe hypertriglyceridemia Learn more

(VICTORIA) A Randomized Parallel-Group, Placebo-Controlled, Double-Blind, Event-Driven, Multi-Center Pivotal Phase III Clinical Outcome Trial of Efficacy and Safety of the Oral sGC Stimulator Vericiguat in Subjects With Heart Failure With Reduced Ejection Fraction(HFrEF)- VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection Fraction (VICTORIA) (MK1242-001) Learn more

(AEROVANC)  A Phase III, Randomized, Double-blind, Placebo-controlled Study of AeroVanc for the Treatment of Persistent Methicillin-resistant Staphylococcus Aureus Lung Infection in Cystic Fibrosis Patients Learn more

(APPLAUD) A Double-Blind, Randomized, Placebo-Controlled, Phase II Study of the Efficacy and Safety of LAU-7b in the Treatment of Cystic Fibrosis in Adults Learn more

(GALAXY) Multicenter Study of Patient-reported Gastrointestinal Symptoms in People With Cystic Fibrosis (GALAXY-OB-18) Learn more 

(PICC CF) Prospective study of peripherally inserted venous catheters in CF patients Learn more

(PTI-801-01) A Multi-Center, Randomized, Placebo-Controlled, Phase 1, Two-Part Study Designed to Assess the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interactions of PTI-801 in Healthy Volunteers, and Safety, Tolerability, and Pharmacokinetics of PTI-801 in Subjects With Cystic Fibrosis Learn more

(RESTORE-CF [Translate Bio]) A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Combined Single and Multiple Ascending Dose Study Evaluating the Safety, Tolerability, and Biological Activity of MRT5005 (CO-hCFTR mRNA/ICE LNP) Administered by Nebulization to Adult Subjects with Cystic Fibrosis Learn more

(TEACH) Testing the Effect of Adding Chronic Azithromycin to Inhaled Tobramycin. A randomized, placebo-controlled, double-blinded trial of azithromycin 500mg thrice weekly in combination with inhaled tobramycin Learn more

(Vertex NextGen 105) A Phase 3, Open-Label Study for Evaluating the Long-Term Safety and Efficacy of VX-445 Combination Therapy in Subjects with Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation Learn more

(ONSD Study) Measuring Optic Nerve Sheath Diameter after Cardiac Arrest: a Pilot Study

(Brown Fat Study) Anti-Diabetic Potential of Exosomes Secreted From Brown Adipose Tissue (BAT) after Bariatric Surgery

(ATHN2) A Longitudinal, Observational Study of Previously Treated Hemophilia Patients Switching Factor Replacement Products Learn more

(ATHN7) A Natural History Cohort Study of the Safety, Effectiveness, and Practice of Treatment for People With Hemophilia Learn more

(Community Counts) CDC Public Health Surveillance for Bleeding Disorders – Registry for Bleeding Disorders Surveillance

(Early Lyme) Use of Circulating Plasmablasts in the Diagnosis of Early Lyme Disease

(Rural HeART Study) Rural Harm REduction Access and Regional Trends (Rural HeART)

(ALLENA ALLN-177) Evaluate the Safety and Efficacy of ALLN-177 in Patients with Enteric Hyperoxaluria: A Phase III Randomized, Placebo-Controlled Study Learn more

(DART) Decision Aid for Renal Therapy: Promoting Knowledge and Autonomy in Chronic Kidney Disease Patients and their Care-Partners (DART). Learn more

(PROTECT) Phase 3, Randomized, Open-Label, Active-Controlled Study Evaluating The Efficacy And Safety Of Oral Vadadustat For The Maintenance Treatment Of Anemia In Subjects With Non-Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) (PRO2TECT – Conversion) Learn more

(RETROPHIN) A Randomized, Multicenter, Double-Blind, Parallel, Activecontrol Study Of The Effects Of Sparsentan, A Dual Endothelin Receptor And Angiotensin Receptor Blocker, On Renal Outcomes In Patients With Primary Focal Segmental Glomerulosclerosis (FSGS) Learn more

(CHARM) Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction Learn more

(CREAD OLE)  A Multicenter, Open-Label, Long-Term Extension Of Phase III Studies (BN29552/BN29553) Of Crenezumab In Patients With Alzheimer’s Disease Learn more

(DAYBREAK) Protocol I8D-MC-AZET A Randomized, Double-Blind, Placebo-Controlled and Delayed-Start Study of LY3314814 in Mild Alzheimer’s Disease Dementia (The DAYBREAK Study) Learn more

(ENSEMBLE) An Open-Label, Single-Arm Study To Evaluate The Effectiveness And Safety Of Ocrelizumab In Patients With Early Stage Relapsing Remitting Multiple Sclerosis Learn more

(EP0088) Multicenter 1-Year Observational Study Of Patients Who Are Initiating Brivaracetam

(HASH4) Neuroinflammatory Response and Headache Control in Patients after Subarachnoid Hemorrhage (HASH4-CSF)Learn more 

(INSYTE) Management of Parkinson’s Disease Psychosis in Actual Practice Learn more

(POP)  Plegridy (Peginterferon B-LA) Real World Effectiveness And Safety Observational Program Learn more

(PRESENCE [HBEH]) A Study of LY3154207 in Participants With Parkinson’s Disease Dementia (PRESENCE) Learn more

(RESTORE) A clinical study of patients with symptomatic neurogenic orthostatic hypotension to assess sustained effects of droxidopa therapy Learn more

(SETPOINT2) Stroke-Related Early Tracheostomy versus Prolonged Orotracheal Intubation in Neurocritical care Trial 2 Learn more

(StATES) A Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Subjects with Epilepsy with a Predictable Seizure Pattern Learn more

(YKP25) A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Cenobamate Adjunctive Therapy in Subjects with Primary Generalized Tonic-Clonic Seizures Learn more

(CREST 2) Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial Learn more

(CREST-H) Carotid Revascularization and Medical Management for Asymptomatic Carotid stenosis – Hemodynamics (CREST-H) Learn more

(NANO) Effectiveness and Safety of Small Aneurysm Coiling Trial Learn more

(TRAP) Aspiration Retriever Technique (ARTS) for Endovascular Stroke Intervention Data Registry Learn more

(CAPE)  A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of Humira® (Adalimumab) in Pediatric Patients with Moderately to Severely Active Crohn’s Disease (CD) – CAPE Learn more

(GO ID) Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers Learn more

(Daily Life) Affect, Thought, and Social context in the Daily Life of Adolescents and Young Adults

(ECT) ECT in the Treatment of Dementia with Behavioral Disturbance: An Observational Study of Current Practice

(VEGF Study)  Vascular endothelial growth factor (VEGF) in post-myocardial infarction (MI) depression: a pilot study

(ACCUTE) Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Study of AB103 As Compared to Placebo in Patients with Necrotizing Soft Tissue Infections (NSTI)(ACUTE) Learn more

(CODA) The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial Learn more

(BEST-CLI)  Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia Learn more

(CREST 2) Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial Learn more

(CREST-H) Carotid Revascularization and Medical Management for Asymptomatic Carotid stenosis – Hemodynamics (CREST-H) Learn more

(EVAS 1) Prospective, Multicenter, Single Arm Safety and Effectiveness Study of Endovascular Abdominal Aortic Aneurysm Repair Using the Nellix® System: A Pivotal and Continued Access Study Learn more

(MATH VTE) Monotherapy Anticoagulation To expedite Home treatment of venous thromboembolism (MATH VTE) Learn more

(CTHRC1) Serum Concentrations of the blood factor Collagen triple helix repeat containing 1 (CTHRC1) in Adult XX Genetic Females with Elevated Serum Testosterone Concentrations: A Pilot Project

(MRG Estradiol) Initial Evaluation of Safety and Efficacy of Administration of Estradiol by Subcutaneous Injections: A Pilot study in Male-to-Female Transgender Patients