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Welcome to the Clinical Trials Office 

As you consider treatment options for yourself or your loved one, you may consider participation in a clinical trial. The resources below provide general and specific information that can help you navigate the clinical trial process.

Current Clinical Trials

Below is a list of enrolling clinical trials at MaineHealth.  Studies can open and close quickly so please contact the Clinical Trials Office directly or speak with your healthcare professional if you are interested in learning more about one of the trials.  You can reach the Clinical Trials Office at 207-396-8670 or email at clinicalresearch@mmc.org.  The following list was updated on 10.25.19.

For a complete list of trials open in the U.S. and abroad, visit www.clinicaltrials.gov.

(MOST) Prospective, Longitudinal, Non-Interventional Study Of Disease Burden And Treatment Of Patients With Low-Risk Myelofibrosis (MF) Or High-Risk Essential Thrombocythemia (ET) Or ET Patients Receiving ET-Directed Therapy  Learn more

(S1826) A Phase III, Randomized Study of Nivolumab (OPDIVO) Plus AVD or Brentuximab Vedotin (ADCETRIS) Plus AVD in Patients (Age >\= 12 years) with Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma Learn more

 

(A011401) Randomized Phase III Trial Evaluating The Role Of Weight Loss In Adjuvant Treatment Of Overweight And Obese Women With Early Breast Cancer (BWEL)  Learn more

(A011502) A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for HER2 Negative Breast Cancer: The ABC Trial Learn more

(ASPIRE) A Phase II Multi-institutional Study of Concurrent Radiotherapy, Palbociclib, and Hormone Therapy for Treatment of Bone Metastasis in Breast Cancer Patients (Winship 4472-18) Learn more

(BR003) A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer Learn more

(BR004) A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab With Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer Learn more

(CCTG MA.39) TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer Learn more

(FABREC) Study of Radiation Fractionation on Patient Outcomes After Breast REConstruction (FABREC) for Invasive Breast Carcinoma Learn more

(NOHA in BRCA) A Pilot Study of NOHA levels in BRCA positive Breast Cancer

(NOHA in TNBC) A Pilot Study of NOHA as a monitoring biomarker in triple negative breast cancer (TNBC)

(RTOG 1304/ NSABP B-51) A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy Learn more

(S1418) A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer With = 1 CM Residual Invasive Cancer or Positive Lymph Nodes (ypN+) After Neoadjuvant Chemotherapy Learn more

(COG AALL15P1)  A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine (IND# 133688, NSC# 102816) to Chemotherapy in Infants with Acute Lymphoblastic Leukemia (ALL) and KMT2A (MLL) Gene Rearrangement Learn more

(COG AALL1621) A Phase 2 Study of Inotuzumab Ozogamicin (NSC# 772518, IND# 133494) in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL) Learn more

(COG AALL1631) International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Testing Imatinib in Combination With Two Different Cytotoxic Chemotherapy Backbones Learn more

(COG AALL1731) A Phase 3 Trial Investigating Blinatumomab (IND# 117467, NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients with Localized B-Lymphoblastic Lymphoma (B-LLy) Learn more

(COG ACNS1422) A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients Learn more

(COG AGCT1531) A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Learn more

(COG AHEP1531) Pediatric Hepatic Malignancy International Therapeutic Trial (PHITT) Learn more

(COG ALTE11C2) Health Effects After Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy Learn more

(COG ANBL00B1) Neuroblastoma Biology Studies Learn more

(COG ANBL1232) Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients With Non-High-Risk Neuroblastoma Learn more

(COG ANBL1531) A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children With Newly Diagnosed High-Risk Neuroblastoma (NBL) Learn more

(COG ANHL12P1) A Randomized Phase 2 Trial of Brentuximab Vedotin (SGN35, NSC# 749710), or Crizotinib (NSC#749005, commercially labeled) in Combination with Chemotherapy for Newly Diagnosed Patients with Anaplastic Large Cell Lymphoma (ALCL) IND # 117117 Learn more

(COG APEC14B1) Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study Learn more

(COG APEC1621C) NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)- Phase 2 Subprotocol of Tazemetostat in Patients With Tumors Harboring Alterations in EZH2 or Members of the SWI/SNF Complex Learn more

(COG AREN03B2) Renal Tumors Classification, Biology, and Banking Study Learn more

(COG ARST1431) A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating With Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864) in Patients With Intermediate Risk (IR) Rhabdomyosarcoma (RMS) Learn more

(COG AALL1521)  A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia Learn more

(COG AALL1731) A Phase 3 Trial Investigating Blinatumomab ( NSC# 765986) in Combination With Chemotherapy in Patients With Newly Diagnosed Standard Risk or Down Syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients With Localized B-Lymphoblastic Lymphoma (B-LLy) Learn more

(COG NCI Pediatric MATCH) COG Pediatric Molecular Analysis for Therapy Choice Screening Protocol Learn more

(A021502) Randomized Trial of Standard Chemotherapy Alone or Combined With Atezolizumab as Adjuvant Therapy for Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair Learn more

(GI004) Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy With or Without Atezolizumab or Atezolizumab Monotherapy in the First-Line Treatment of Patients With Deficient DNA Mismatch Repair (dMMR) Metastatic Colorectal Cancer Learn more

(S1815) A Phase III Randomized Trial of Gemcitabine, Cisplatin, and Nab-Paclitaxel Versus Gemcitabine and Cisplatin in Newly Diagnosed, Advanced Biliary Tract Cancers Learn more

(A031501) Phase III Randomized Adjuvant Study of MK-3475 (Pembrolizumab) in Muscle Invasive and Locally Advanced Urothelial Carcinoma (AMBASSADOR) Versus Observation Learn more

(EA8143) A Phase 3 Randomized Study Comparing Perioperative Nivolumab vs. Observation in Patients With Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC) Learn more

(EA8153) Cabazitaxel With Abiraterone Versus Abiraterone Alone Randomized Trial for Extensive Disease Following Docetaxel: The CHAARTED2 Trial Learn more

(GU005) Phase III IGRT and SBRT vs IGRT and Hypofractionated IMRT for Localized Intermediate Risk Prostate Cancer Learn more

(GU006) Radiation Therapy With or Without Apalutamide in Treating Patients With Stage III-IV Prostate Cancer Learn more

(S1802) Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer Learn more

(S1806) Phase III Randomized Trial of Concurrent Chemoradiotherapy With or Without Atezolizumab in Localized Muscle Invasive Bladder Cancer Learn more

(STEEL) A Trial to See What the Results Are for Radiation Therapy and Hormone Therapy vs Radiation Therapy With Enhanced Hormone Therapy With Enzalutamide for Patients With PSA Recurrence After Surgery (STEEL) Learn more

(FIRST 3000-03-005)  ENGOT-0V44 The FIRST (First-line Ovarian Cancer Treatment With Niraparib Plus TSR-042) Study: A Randomized, Double-Blind, Phase 3 Comparison of Platinum-Based Therapy With TSR-042 and Niraparib Versus Standard of Care Platinum-Based Therapy as First-Line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer Learn more

(GOG 0238) A Randomized Trial of Pelvic Irradiation With or Without Concurrent Weekly Cisplatin in Patients With Pelvic-Only Recurrence of Carcinoma of the Uterine Corpus Learn more

(GOG 3020 ATHENA) A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy Learn more

(GY005) A Randomized Phase II/III Study of the Combination of Cediranib and Olaparib Compared to Cediranib or Olaparib Alone, or Standard of Care Chemotherapy in Women with Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (COCOS) Learn more

(GY018) A Phase III Randomized, Placebo-Controlled Study of Pembrolizumab (MK-3475, NSC #776864) in Addition to Paclitaxel and Carboplatin for Measurable Stage III or IVA, Stage IVB or Recurrent Endometrial Cancer Learn more

(LEAP-001) A Phase 3 Randomized, Open-Label, Study of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for First-line Treatment of Advanced or Recurrent Endometrial Carcinoma Learn more

(RTOG 1171/ GOG 0263) A Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated with Initial Radical Hysterectomy and Pelvic Lymphadenectomy Learn more

(TSR-042) A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-042, an Anti-PD-1 Monoclonal Antibody, in Patients With Advanced Solid Tumors Learn more

(S1616) A Phase II Randomized Study of Nivolumab (NSC-748726) With Ipilimumab (NSC-732442) or Ipilimumab Alone in Advanced Melanoma Patients Refractory to an Anti-PD1 or Anti-PD-L1 Agent Learn more

(BN003)  Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma Learn more

(BN005) A Phase II Randomized Trial of Proton Vs. Photon Therapy (IMRT) for Cognitive Preservation in Patients With IDH Mutant, Low to Intermediate Grade Gliomas Learn more

(ChemoID Assay) Standard Chemotherapy Versus Chemotherapy Chosen by Cancer Stem Cell Chemosensitivity Testing in the Management of Patients With Recurrent Glioblastoma Multiforme (GBM). Learn more

(EAY131-Z1G) Phase II Study of Copanlisib in Patients with Tumors with PTEN Loss by IHC and any PTEN Sequencing Result Learn more

(HN005) A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer Learn more

(MATCH) EAY-131:  Molecular Analysis for Therapy Choice (MATCH) Learn more

(MCGI)  The Maine Cancer Genomics Initiative (MCGI):  A Study of Oncology Clinician and Patient Experiences with Clinical Genomics in Maine (051817v1)

(S1612) A Randomized Phase II/III Trial of “Novel Therapeutics” Versus Azacitidine in Newly Diagnosed Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS), Age 60 or Older LEAP: Less-Intense AML Platform Trial Learn more

(S1702)  A Phase II Study of Isatuximab (SAR650984) (NSC-795145) for patients with previously treated AL AMYLOIDOSIS Learn more

(A081105) Randomized Study Of Erlotinib Vs Observation In Patients With Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung Cancer (NSCLC) Learn more

(A151216) Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST) Learn more

(CASTL) Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites Learn more

(E4512) A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein Learn more

(EAY131-A) MATCH Treatment Subprotocol A: Phase II Trial of Afatinib in Patients with Solid Tumors (Other Than Small Cell and Non-Small Cell Lung Cancer) or Lymphomas, That Have Activating Mutations of EGFR and Have Progressed After Standard Treatment Learn more

(LU005) Limited Stage Small Cell Lung Cancer (LS-SCLC): A Phase II/III Randomized Study of Chemoradiation Versus Chemoradiation Plus Atezolizumab Learn more

(LUNGMAP) A Master Protocol to Evaluate Biomarker-Driven Therapies and Immunotherapies in Previously-Treated Non-Small Cell Lung Cancer (Lung-MAP Screening Study) Learn more

(LUNGMAP-S1900A) A Phase II Study Of Rucaparib In Patients With Genomic LOH HIGH And/Or Deleterious BRCA1/2 Mutation Stage IV Or Recurrent Non-Small Cell Lung Cancer (LUNGMAP Sub-Study) Learn more

(PACIFIC-4)  A Phase III, Randomized, Placebo-controlled, Double-blind, Multi-center, International Study of Durvalumab Following Stereotactic Body Radiation Therapy (SBRT) for the Treatment of Patients With Unresected Stage I/II, Lymph-node Negative Non-small Cell Lung Cancer (PACIFIC-4/RTOG-3515) Learn more

(RESILIENT) A Randomized, Open Label Phase 3 Study of Irinotecan Liposome Injection (ONIVYDE®) Versus Topotecan in Patients With Small Cell Lung Cancer Who Have Progressed on or After Platinum-based First-Line Therapy Learn more

(S1400-F) A Phase II Study of MEDI4736 (Durvalumab) Plus Tremelimumab as Therapy for Patients With Previously Treated Anti-PD-1/PD-L1 Resistant Stage IV Squamous Cell Lung Cancer (Lung-Map Non-Match Sub-Study) Learn more

(S1900-A) A Phase II Study of Rucaparib in Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-Small Cell Lung Cancer (LUNG-MAP Sub-Study) Learn more

(ASTELLAS AKI ASP1128) A Phase 2 Proof of Concept, Double-blind, Randomized, Placebo-controlled Study to Evaluate the
 Efficacy of ASP1128 (MA-0217) in Subjects at Risk for Acute Kidney Injury following Coronary Artery Bypass Graft (CABG) and/or Valve Surgery Learn more

(BELIEVE) Behavior of valve Leaflets and the Incidence of reduced mobility post-surgical aortic valve implant Learn more

(Cardiometabolic Study) Molecular Assessment of Human Cardiometabolic Disease

(Mediterranean Diet) A Comparison Of Mediterranean Diet Vs. Standard Diet In CABG Patients On The Cardiac Cell Signaling And Composition Of Lipid Content Learn more

(ON-X 17mm Valve) ON-X® PROSTHETIC HEART VALVE 17mm AORTIC 23mm MITRAL Learn more

(REFRESH II) Cytosorb® Reduction Of Free Hemoglobin/Acute Kidney Injury (AKI) During Cardiac Surgery Learn more

(SIRT-CVS)  Short Interval Resveratrol in Cardiovascular Surgery (SIRT-CVS) Trial

(ABSORB) A Clinical Evaluation of Absorb BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Lesions Learn more

(AEGIS II) A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome Learn more

(ARTESiA) Apixaban for the Reduction of Thrombo-Embolism in Patients with Device-Detected Sub-Clinical Atrial Fibrillation Learn more

(ASAP TOO) Assessment of the WATCHMAN Device in Patients Unsuitable for Oral Anticoagulation Learn more

(CARILLON)  Assessment of the CARILLON® Mitral Contour System® in Treating Functional Mitral Regurgitation Associated with Heart Failure Learn more

(DAL-GENE) A Phase III, Double-blind, Randomized Placebo-controlled Study to Evaluate the Effects of Dalcetrapib on Cardiovascular (CV) Risk in a Genetically Defined Population With a Recent Acute Coronary Syndrome (ACS): The Dal-GenE Trial Learn more

(EARLY TAVR) Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients with AsYmptomatic Severe Aortic Stenosis: EARLY TAVR trial Learn more

(ECLIPSE) Evaluation of Treatment Strategies for Severe Calcific Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting Stents Learn more

(ENVISAGE) Clinical Study Protocol Edoxaban Versus Standard Of Care And Their Effects On Clinical Outcomes In Patients Having Undergone Transcatheter Aortic Valve Implantation – In Atrial Fibrillation Edoxaban (DU-176B-C-U4001) ENVISAGE-TAVIAF Learn more

(GALACTIC HF) A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects With Chronic Heart Failure With Reduced Ejection Fraction Learn more

(HEART FID) A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Injectafer® (Ferric Carboxymaltose) as Treatment for Heart Failure With Iron Deficiency Learn more

(OPTIMIZE) The OPTIMIZE Trial to Assess the Procedural and Clinical Value of the Svelte IDS and RX Sirolimus-Eluting Coronary Stent Systems for the Treatment of Atherosclerotic Lesions in a Randomized Study Learn more

(PERSPECTIVE) A multicenter, randomized, double-blind, active-controlled study to evaluate the effects of LCZ696 compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction Learn more

(PROMINENT) Pemafibrate To Reduce Cardiovascular Outcomes By Reducing Triglycerides In Patients With Diabetes Learn more

(TRILOGY / CaPre) A Phase 3, multi-center, placebo-controlled, randomized, double-blind 26-week study to assess the safety and efficacy of CaPre® in patients with severe hypertriglyceridemia Learn more

(VICTORIA) A Randomized Parallel-Group, Placebo-Controlled, Double-Blind, Event-Driven, Multi-Center Pivotal Phase III Clinical Outcome Trial of Efficacy and Safety of the Oral sGC Stimulator Vericiguat in Subjects With Heart Failure With Reduced Ejection Fraction(HFrEF)- VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection Fraction (VICTORIA) (MK1242-001) Learn more

(APPLAUD) A Double-Blind, Randomized, Placebo-Controlled, Phase II Study of the Efficacy and Safety of LAU-7b in the Treatment of Cystic Fibrosis in Adults Learn more

(PICC CF) Prospective study of peripherally inserted venous catheters in CF patients Learn more

(RESTORE-CF [Translate Bio]) A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Combined Single and Multiple Ascending Dose Study Evaluating the Safety, Tolerability, and Biological Activity of MRT5005 (CO-hCFTR mRNA/ICE LNP) Administered by Nebulization to Adult Subjects with Cystic Fibrosis Learn more

(TEACH) Testing the Effect of Adding Chronic Azithromycin to Inhaled Tobramycin. A randomized, placebo-controlled, double-blinded trial of azithromycin 500mg thrice weekly in combination with inhaled tobramycin Learn more

 

(ONSD Study) Measuring Optic Nerve Sheath Diameter after Cardiac Arrest: a Pilot Study

(Brown Fat Study) Anti-Diabetic Potential of Exosomes Secreted From Brown Adipose Tissue (BAT) after Bariatric Surgery

(ATHN2) A Longitudinal, Observational Study of Previously Treated Hemophilia Patients Switching Factor Replacement Products Learn more

(ATHN7) A Natural History Cohort Study of the Safety, Effectiveness, and Practice of Treatment for People With Hemophilia Learn more

(ATHN 8) US Cohort Study of Previously Untreated Patients (PUPs) With Congenital Hemophilia Learn more

(ATHN 9) A Natural History Cohort Study of the Safety, Effectiveness, and Practice of Treatment for People With Severe Von Willebrand Disease (VWD) Learn more

(Community Counts) CDC Public Health Surveillance for Bleeding Disorders – Registry for Bleeding Disorders Surveillance

(Early Lyme) Use of Circulating Plasmablasts in the Diagnosis of Early Lyme Disease

(Rural HeART Study) Rural Harm REduction Access and Regional Trends (Rural HeART)

(ALLENA ALLN-177) Evaluate the Safety and Efficacy of ALLN-177 in Patients with Enteric Hyperoxaluria: A Phase III Randomized, Placebo-Controlled Study Learn more

(DART) Decision Aid for Renal Therapy: Promoting Knowledge and Autonomy in Chronic Kidney Disease Patients and their Care-Partners (DART). Learn more

(IMAGINE) A Pivotal Phase 3 Trial To Evaluate The Safety And Efficacy Of Clazakizumab For The Treatment Of Chronic Active Antibody-Mediated Rejection In Kidney Transplant Recipients Learn more

(PROTECT) Phase 3, Randomized, Open-Label, Active-Controlled Study Evaluating The Efficacy And Safety Of Oral Vadadustat For The Maintenance Treatment Of Anemia In Subjects With Non-Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) (PRO2TECT – Conversion) Learn more

(RETROPHIN) A Randomized, Multicenter, Double-Blind, Parallel, Activecontrol Study Of The Effects Of Sparsentan, A Dual Endothelin Receptor And Angiotensin Receptor Blocker, On Renal Outcomes In Patients With Primary Focal Segmental Glomerulosclerosis (FSGS) Learn more

(CHARM) Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction Learn more

(EP0088) Multicenter 1-Year Observational Study Of Patients Who Are Initiating Brivaracetam

(HASH4) Neuroinflammatory Response and Headache Control in Patients after Subarachnoid Hemorrhage (HASH4-CSF)Learn more 

(INSYTE) Management of Parkinson’s Disease Psychosis in Actual Practice Learn more

(POP)  Plegridy (Peginterferon B-LA) Real World Effectiveness And Safety Observational Program Learn more

(RESTORE) A clinical study of patients with symptomatic neurogenic orthostatic hypotension to assess sustained effects of droxidopa therapy Learn more

(SETPOINT2) Stroke-Related Early Tracheostomy versus Prolonged Orotracheal Intubation in Neurocritical care Trial 2 Learn more

(StATES) A Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Subjects with Epilepsy with a Predictable Seizure Pattern Learn more

(XPF-201) A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 as Adjunctive Therapy in Focal-onset Epilepsy Learn more

(YKP25) A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Cenobamate Adjunctive Therapy in Subjects with Primary Generalized Tonic-Clonic Seizures Learn more

(YKP33) A Multicenter Open-label Extension Study to Evaluate the Long-term Safety of Cenobamate Adjunctive Therapy in Subjects with Primary Generalized Tonic-Clonic Seizures Learn more

(CREST 2) Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial Learn more

(CREST-H) Carotid Revascularization and Medical Management for Asymptomatic Carotid stenosis – Hemodynamics (CREST-H) Learn more

(NANO) Effectiveness and Safety of Small Aneurysm Coiling Trial Learn more

 

(CAPE)  A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of Humira® (Adalimumab) in Pediatric Patients with Moderately to Severely Active Crohn’s Disease (CD) – CAPE Learn more

(GO ID) Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers Learn more

(Daily Life) Affect, Thought, and Social context in the Daily Life of Adolescents and Young Adults

(ECT) ECT in the Treatment of Dementia with Behavioral Disturbance: An Observational Study of Current Practice

(VEGF Study)  Vascular endothelial growth factor (VEGF) in post-myocardial infarction (MI) depression: a pilot study

(CODA) The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial Learn more

(BEST-CLI)  Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia Learn more

(CREST 2) Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial Learn more

(CREST-H) Carotid Revascularization and Medical Management for Asymptomatic Carotid stenosis – Hemodynamics (CREST-H) Learn more

(EVAS 1) Prospective, Multicenter, Single Arm Safety and Effectiveness Study of Endovascular Abdominal Aortic Aneurysm Repair Using the Nellix® System: A Pivotal and Continued Access Study Learn more

(MATH VTE) Monotherapy Anticoagulation To expedite Home treatment of venous thromboembolism (MATH VTE) Learn more

(CTHRC1) Serum Concentrations of the blood factor Collagen triple helix repeat containing 1 (CTHRC1) in Adult XX Genetic Females with Elevated Serum Testosterone Concentrations: A Pilot Project

(MRG Estradiol) Initial Evaluation of Safety and Efficacy of Administration of Estradiol by Subcutaneous Injections: A Pilot study in Male-to-Female Transgender Patients