For there to be successful medical research, an institution must have top core lab resources.  Maine Medical Center Research Institute (MMCRI) has a series of shared resources and core facilities dedicated to providing the latest equipment and knowledge necessary to assist researchers in their work.

Many of these shared resources and services are available to the outside community.

Molecular and Cell Biology Related

  • Automated nucleic acid purification and microfluidics separation system
  • DNA sequencing
  • Quantitative real-time PCR
  • Mass spectrometry for proteomics and lipodomics
  • Viral expression vector production

Microscopy

  • Confocal microscopy and FRET
  • Four color epifluorescence microscopy
  • Automated 4 color epifluorescence live cell microscopy

Flow Cytometry, Cell Sorting, and Cell Analysis

  • flow cytometry
  • fluorescence activated cell sorting
  • magnetic microbead cell separation
  • high throughput fluorimetric and luminometer assays

Tissue Specimen Collection and Histopathology

  • human tissue bank of normal and diseases specimens
  • tissue processing, sectioning, and routine histology stains
  • panel of standard immunostaining protocols
  • tissue microarrays

Immunoassays

  • high throughput clinical analysis of metabolic panels
  • enzyme-linked immunoassays
  • colorimetric and radioimmunoassays
  • mouse and human metabolic and disease biomarkers

Mouse Models and Their Phenotyping

  • AAALAC accredited rodent housing
  • Mouse transgenic facility
  • Mouse re-derivation and cryopreservation services
  • Small animal magnetic resonance imaging (7T)
  • Microcomputed tomography
  • Small animal NMR
  • High resolution ultrasound
  • Metabolic cages
  • Cell and tissue metabolism analyzer (Seahorse)

Clinical & Translational Research Infrastructure