COBRE in Mesenchymal and Neural Regulation of Metabolic Networks 2017-11-03T12:07:58+00:00

COBRE in Mesenchymal and Neural Regulation of Metabolic Networks

Building research excellence in understanding causes of metabolic disease

COBRE NEWS

Administration of the COBRE Program

This COBRE program at Maine Medical Center is led by Dr. Lucy Liaw, Program Director, with support from Dr. Clifford Rosen, Director of the Center for Clinical and Translational Research, and Dr. Irwin Brodsky, Clinical Advisor. This program is supported by the National Institute of General Medical Sciences, National Institutes of Health, Award Number GM121301.  

Our intent is to build a strong research center focused on the diseases of metabolism, including obesity, diabetes, and osteoporosis.

The overall program has four major goals:

  1. Provide the leadership, governance, and advisory network to establish a new scientific program in mesenchymal progenitor cell biology and neural signaling to gain novel insights into the mechanisms underlying metabolic health and disease.

  2. Provide project and mentorship support to launch the careers of promising junior investigators within this scientific program and help ensure their long-term scientific success as independent researchers.

  3. Enhance the capabilities of our core facilities to support our COBRE investigators and other institutional and external researchers, and to stimulate innovative research methodologies and new collaborations.

  4. Establish a pilot project program to focus on translational opportunities related to metabolic disease.

COBRE Overview Video

COBRE Projects

This program supports four young investigators with exciting collaborative projects studying brown adipose tissue, adipocytes in the bone marrow compartment, decreasing fracture risk in nursing home residents on anti-psychotic medications, and how the brain-bone connection regulates bone loss as a side effect of anti-psychotic medications. As these investigators become competitive to achieve independent grant funding, we will be able to recruit new talent to our Center.

Dr. Aaron Brown is the lead scientist on Project 1 of the COBRE. His project focuses on the regulation of obesity through BMP signaling pathways in brown adipose tissue.  Learn More.

Dr. Michaela Reagan is the lead scientist on Project 2 of the COBRE. Her project addresses novel mechanisms of osteocyte control of marrow adiposity. Learn More.

Dr. Christine Duarte is the lead scientist on Project 3 of the COBRE. Her project addresses beta blockers and their impact on fracture risk in nursing home residents taking atypical antipsychotics. Learn More.

Dr. Katie Motyl is the lead scientist on Project 4 of the COBRE. Her project complements Project 3 and focuses on neural and metabolic mechanisms of atypical antipsychotic drug-induced bone loss. Learn More.

COBRE Cores

This program also supports three scientific core facilities that use state-of-the-art technologies to perform global analysis of protein and lipid profiles, analyze the histopathology of tissues, and measure metabolic activity at the organism and cellular levels.

Dr. Volkhard Lindner is head of the Histopathology and Histomorphometry Core. Learn more about this Core and the Metabolic COBRE.

Dr. Cliff Rosen is head of the Physiology Core for the Mesenchymal and Neural Regulation of Metabolic Networks (PCMN).  Learn More about this Core and the Metabolic COBRE.

Dr. Cal Vary is head of the Proteomics and Lipidomics Core. Learn more about this Core and the Metabolic COBRE.

External Advisory Board

This Board provides scientific direction and guidance, consisting of national experts in the field.

  • Thomas Landes Clemens PhD, Chair, Professor of Orthopaedic Surgery Johns Hopkins Medicine
  • Pamela Duncan PhD Professor of Neurology Wake Forest School of Medicine
  • Gerard Karsenty MD, PhD Professor and Chair Department of Genetics and Development Columbia University Medical Center
  • Evan Rosen MD, PhD Professor of Medicine Beth Israel Deaconess Medical Center Institute Member, Broad Institute 

Steering Committee

This committee is comprised of research professionals in Maine with scientific and programmatic leadership expertise.

This program is supported by the National Institute of General Medical Sciences, National Institutes of Health, Award Number GM121301.   The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.