Small Animal Imaging

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Small Animal Imaging2018-04-09T16:01:30+00:00

Small_Animal_Image

The Small Animal Imaging Facility provides magnetic resonance imaging, high-resolution computed tomography (µCT), and high-resolution ultrasound imaging. The equipment includes a BRUKER PharmaScan 7T, 300 MHz imager with a resolution of 90 µm. Magnetic resonance imaging (MRI) is a non-invasive method that is utilized to look at anatomy and physiology in mice. Our animal facility provides non-barrier housing for external investigators with some exceptions concerning the health status of mice.

Services Available:

  • Any anatomical/morphological images of all organs.
  • Magnetic resonance angiography, non-contrast enhanced and contrast enhanced
  • Proton spectroscopy, global and localized (for example: assessment of water:fat ratios in bone marrow).
  • Cardiac imaging, diastolic and systolic dimensions of the ventricle, cardiac movies, cardiac movies, late gadolinium, enhancement of cardiac infarcts, cardiac scar evaluation, and size determination.
  • In-utero assessment of embryo development/embryonic defects or determination of the time point for the loss/resorption of transgenic embryos, and high resolution embryo imaging (~27 µm).
  • Targeted contrast enhanced imaging using your specific antibody that is conjugated to gadolinium.

µCT (Viva40, Scanco, 11µm resolution) services are available for bone and isolated tissue specimens including image acquisition and quantification.

Ultrasound (VEVO2100, VisualSonics) imaging is currently only available for mice from approved vendors. Services provided include: anatomical/morphological imaging, tumor volume determination, echocardiography, and targeted and non-targeted microbubble imaging, and blood flow quantification.

 

SERVICE:           MMCRI ACADEMIC COMMERCIAL
Bone Ex-vivo $61.50 $83.13 $96.90
Spleen Ex-vivo $31.00 $43.70 $50.00
Brain Ex-vivo 3D $219.00 $309.70 $367.60
Bone In-vivo $103.50 $147.50 $403.00
Body Fat In-vivo $74.00 $105.00 $285.00
Brain Tumor In-vivo $74.50 $105.50 $285.50
Brain MS Lesions In-vivo with contrast $130.00 $170.80 $410.00
Cardio In-vivo $94.20 $133.00 $358.00
Prostate T1&T2 In-vivo with contrast (no kidney) $128.60 $170.00 $409.25
Mammary Gland In-vivo with contrast $101.30 $132.30 $312.30
Lung In-vivo with contrast $101.90 $132.90 $312.90
Liver T2, T1 & Angio In-vivo $94.00 $132.70 $357.70
Kidney Angio In-vivo $76.35 $107.35 $287.35
Brain Angio In-vivo $76.35 $107.35 $287.35
Hind Limb Angio & Calves In-vivo $91.80 $130.50 $355.50

References:

  1. Devlin MJ, Cloutier AM, Thomas NA, Panus DA, Lotinun S, Pinz I, Baron R, RosenCJ, Bouxsein ML. Caloric restriction leads to high marrow adiposity and low bone mass in growing mice. J Bone Miner Res. 2010;25(9):2078-88. PMCID: PMC3127399
  2. Yang X, Kilgallen S, Andreeva V, Spicer DB, Pinz I, Friesel R. Conditional expression of Spry1 in neural crest causes craniofacial and cardiac defects. BMC Dev Biol. 2010 May 11;10(1):48. PMCID: PMC2874773
  3. Young K, Conley B A, Romero D, Tweedie E, O’Neill C F, Pinz I, Brogan L, Lindner V, Liaw L, and Vary C P H: BMP9 Regulates Endoglin-dependent Chemokine Responses in Endothelial Cells. Blood. 2012 Nov 15;120(20):4263-73. PMCID: PMC3501721.
  4. Marks P, Preda M, Henderson T, Lindner V, Liaw L, Friesel RE, Pinz IM: Interactive 3D Analysis of Blood Vessel Trees and Collateral Vessel Volumes in Magnetic Resonance Angiograms in the Mouse Ischemic Hindlimb Model. The Open Medical Imaging Journal, 2013, 7, 19-27. PMCID: PMC3929959.
  5. Malaeb S, Davis J, Pinz I, Newman J, Dammann O, Rios M: Effect of sustained postnatal systemic inflammation on hippocampal volume and function in juvenile mice. Pediatr Res. 2014 Oct;76(4):363-9. PMCID: PMC4167932.

Contact Us

Director: Ilka Pinz, PhD
pinzi@mmc.org

Manager: Terry Henderson
hendet@mmc.org