The Maine Medical Center BioBank (MMC BB) provides human biospecimens with annotated clinical data to the research community to aid in the characterization of disease with the goal of improved patient therapies and the advancement of science and personalized medicine.

Logo_CAPExcess surgical tissue and other biospecimens that would otherwise be discarded is de-identified, processed, stored and distributed to research scientists at MMC, MMCRI, other academic institutes, pharmaceutical and biotech companies and commercial specimen repositories.

Biospecimen Request Form

Investigators may submit a request for samples by completing the form above.

Contact: the BioBank tbteam@mmc.org for more information.

More than 50,000 samples with annotated data collected primarily from cancer and inflammatory disease surgeries, are available to investigators in fresh, frozen or FFPE (formalin fixed-paraffin embedded) sample formats.

Tissue microarrays, constructed by the MMCRI Histopathology Core are also available upon request. Sample inventory and tracking is managed by Progeny software.

The MMC BioBank (BB) operates under an Institutional Review Board (IRB) approved protocol and is overseen by the MMCRI Office of Research Compliance.

The MMC BB is accredited by the College of American Pathologists (CAP) and its operations are guided by NCI Best Practices for Biorepositories and by the International Society of Biological and Environmental Repositories (IBSER).

The Cancer Genome Atlas (TCGA)

The TCGA has compiled a database of genomic alterations associated with at least 20 different types of cancer to date.  The MMC BioBank has provided tissue from prostate and sarcoma tumors with annotated clinical data to support the TCGA program.

Jackson Laboratory: Patient Derived Xenograft (PDX) Project

Over 300 patient-derived xenograft (PDX) tumors are available for engrafting into immunocompromised NSG™ mice for shipment to your facility or use in JAX-directed preclinical efficacy studies.

Lung Stem Cell Study: Cloning and Characterization of Adult Lung Stem Cells for Understanding Airway Diseases

Ovarian  and Follicular Cancer Study: Cloning and Characterization of Adult Ovarian and Fallopian Tube Stem Cells for Understanding the Etiology of Ovarian Cancer

Esophageal Stem Cell Study: Cloning and Characterization of Barrett’s Esophagus Stem Cells for Risk Assessment and Targeted Therapy Development.

The Maine Triple Negative Breast Cancer Study: Cloning and Characterization of stem cells from the tumors of  triple negative (ER, PR and HER-2/neu) breast cancer patients for development of improved therapies

The goal of the Maine Medical Center Research Institute BioBank is to accelerate the discovery of new and improved medical tests and treatments for our patients by providing researchers access to specific tissue samples.  Research is our best hope for understanding and curing the diseases from which people suffer today.

Donating excess surgical tissue to our BioBank will not alter your treatment or diagnosis in any way. A small portion of the tissue not needed for routine tests would be stored in the tissue bank. Tissue removed from your body during surgery will always be used first to diagnose your medical condition and determine the best course of medical treatment.

When you are asked if you are willing to participate in this project, a BioBanking staff member, usually a research nurse, will explain the donation process and the general nature of the research being done, as well as answer any questions or concerns.

A Consent Form will be given to you for review. The consent form outlines the tissue banking project and highlights your rights as a tissue donor. The one available online is for review only as a true consent must be signed with a research nurse present.

If you decide to donate, you would sign the consent form confirming your willingness to participate. A copy of the signed consent form is given to you for your own records. After the surgery is completed, any tissue that is banked is identified with a barcode, instead of your name, to help ensure confidentiality. The bar code is linked to the medical record in a locked file maintained by the research nurse.

The tissue and related clinical information are made available to researchers at Maine Medical Center Research Institute, universities, clinical trials groups, pharmaceutical companies, or commercial tissue banking companies.

Patients scheduled for surgery at Maine Medical Center for treatment of certain diseases are eligible. Normally we only bank tissue that is related to active research studies. If you are eligible, the Research Nurse will ask if you are interested in participating, either during your preoperative visit or following surgery. At that time you can decide whether or not you are interested in donating any extra surgical tissue to the tissue bank along with the pertinent associated medical record information

Anne Breggia, PhD

Director, BioBank
bregga@mmc.org

Michael Jones, MD

Medical Director, BioBank