Makoto Fujiwara, MD, PhDMakoto Fujiwara

Postdoctoral Fellow


MD: Medicine, Department of Medicine, Osaka University, Japan
PhD: Medicine, Graduate School of Medicine/Faculty of Medicine, Osaka University, Japan

My research is focused on the adipogenic lineage determinants associated with metabolic programming in bone marrow stromal cells. I also interested in function of osteocytes, especially in the regulation mechanisms of SOST and sclerostin expression.

Islam MS, Namba N, Ohata Y, Fujiwara M, Nakano C, Takeyari S, Miyata K, Nakano Y, Yamamoto K, Nakayama H, Kitaoka T, Kubota T, Ozono K. Functional analysis of monocarboxylate transporter 8 mutations in Japanese Allan-Herndon-Dudley syndrome patients. Endocr J. 2018 Oct 25. [Epub ahead of print]

Ueyama K, Namba N, Kitaoka T, Yamamoto K, Fujiwara M, Ohata Y, Kubota T, Ozono K. Endocrinological and phenotype evaluation in a patient with acrodysostosis. Clin Pediatr Endocrinol. 2017;26(3):177-182.

Fujiwara M, Kubota T, Wang W, Ohata Y, Miura K, Kitaoka T, Okuzaki D, Namba N, Michigami T, Kitabatake Y, Ozono K. Successful induction of sclerostin in human-derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2. Bone. 2016 Apr;85:91-8

Wang W, Song MH, Miura K, Fujiwara M, Nawa N, Ohata Y, Kitaoka T, Kubota T, Namba N, Jin DK, Kim OH, Ozono K, Cho TJ. Acromesomelic dysplasia, type maroteaux caused by novel loss-of-function mutations of the NPR2 gene: Three case reports. Am J Med Genet A. 2016 Feb;170A(2):426-434.

Yamamoto K, Namba N, Kubota T, Usui T, Takahashi K, Kitaoka T, Fujiwara M, Hori Y, Kogaki S, Oue T, Morii E, Ozono K.Pheochromocytoma complicated by cyanotic congenital heart disease: a case report. Clin Pediatr Endocrinol. 2016 Apr;25(2):59-65.

Kubota T, Wang W, Miura K, Nakayama H, Yamamoto K, Fujiwara M, Ohata Y, Tachibana M, Kitaoka T, Takakuwa S, Miyoshi Y, Namba N, Ozono K. Serum NT-proCNP levels increased after initiation of GH treatment in patients with achondroplasia/hypochondroplasia. Clin Endocrinol (Oxf). 2016 Jun;84(6):845-50.

Kubota T, Kitaoka T, Miura K, Fujiwara M, Ohata Y, Miyoshi Y, Yamamoto K, Takeyari S, Yamamoto T, Namba N, Ozono K. Serum fibroblast growth factor 23 is a useful marker to distinguish vitamin D-deficient rickets from hypophosphatemic rickets. Horm Res Paediatr. 2014;81(4):251-7.

Kitaoka T, Miyoshi Y, Namba N, Miura K, Kubota T, Ohata Y, Fujiwara M, Takagi M, Hasegawa T, Jüppner H, Ozono K. Two Japanese familial cases of Caffey disease with and without the common COL1A1 mutation and normal bone density, and review of the literature. Eur J Pediatr. 2014 Jun;173(6):799-804.

Fujiwara M, Namba N, Miura K, Kitaoka T, Hirai H, Kondou H, Shimotsuji T, Numakura C, Ozono K. Detection and characterization of two novel mutations in the HNF4A gene in maturity-onset diabetes of the young type 1 in two Japanese families. Horm Res Paediatr. 2013;79(4):220-6

Fujiwara M, Namba N, Ozono K, Arisaka O, Yokoya S; Committee on Drugs, Japanese Society for Pediatric Endocrinology. Treatment of Hypophosphatemic Rickets with Phosphate and Active Vitamin D in Japan: A Questionnaire-based Survey. Clin Pediatr Endocrinol. 2013 Jan;22(1):9-14

Abe S, Namba N, Abe M, Fujiwara M, Aikawa T, Kogo M, Ozono K. Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes. Endocrinology. 2012 Aug;153(8):4049-58.

Miura K, Namba N, Fujiwara M, Ohata Y, Ishida H, Kitaoka T, Kubota T, Hirai H, Higuchi C, Tsumaki N, Yoshikawa H, Sakai N, Michigami T, Ozono K. An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene. PLoS One. 2012;7(8):e42180.

Kitaoka T, Namba N, Miura K, Kubota T, Ohata Y, Fujiwara M, Hirai H, Yamamoto T, Ozono K. Decrease in serum FGF23 levels after intravenous infusion of pamidronate in patients with osteogenesis imperfecta. J Bone Miner Metab. 2011 Sep;29(5):598-605.

Professional Service

  • Journal Article Reviewer, Journal of Bone Mineral Metabolism, 2015 – present

Professional Memberships and Societies

  • Japan Pediatric Society, 2004 – present
  • Japanese Society for Bone and Mineral Research, 2011 – present
  • Japanese Society for Pediatric Endocrinology, 2011 – present
  • American Society for Bone and Mineral Research, 2016 – present

Academic and Professional Development Activities

  • Resident of Department of Pediatrics, Osaka University Medical Hospital, Japan, 2003-2004
  • Medical Staff of Department of Pediatrics, Ikeda Municipal Hospital, Japan, 2004-2006
  • Medical Staff of Department of Pediatrics, Sakai Municipal Hospital, Japan, 2006-2007
  • Medical Staff of Department of Pediatrics, Osaka University Medical Hospital, Japan, 2007-2015
  • Assistant Professor, Course for Oral Sciences, Osaka University Graduate School of Dentistry, Japan, 2015-2017