Postdoctoral Research: Dr. Gupta’s research work focus on generation of kidney organoids from nephron progenitor cells derived from directed differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Further, he is studying in vivo engraftment capability of kidney organoids by their characterization for vascularization, nephron maturation, vascular/tubular connection between host and graft and functional property of nephron segments.
Doctoral Research: Dr. Gupta’s PhD thesis was focused on isolation, characterization and therapeutic evaluation of fetal kidney stem cells in experimental model of acute renal failure (ARF), under the supervision of Prof. Soniya Nityanand, Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP-226014, India. Rat fetal kidney derived stem cells showed various mesenchymal, embryonal and renal progenitor markers. These stem cells exhibited clonal expansion and differentiated into all the three germ layers and also in renal epithelial cells. The administration of fKSC was highly renoprotective in rats with ischemic injury and these beneficial effects of fKSC were predominantly mediated through their anti-apoptotic, anti-inflammatory and antioxidative effects. In addition, these stem cells also showed their angiogenic as well as the renal regenerative potential in cisplatin induced ARF in rats. The study provides a novel potential candidate for the development of cell based therapy for the treatment of different renal diseases. Apart from this PhD work, Dr. Gupta was also involved in the various ongoing projects, where he studied regenerative potential of normoxic as well as hypoxic conditioned amniotic fluid and amniotic membrane derived stem cells and, characterization and therapeutic evaluation of human and rat fetal heart derived stem cells.
A complete list of publications can be found on My NCBI
Garikipati VNS, Singh SP, Mohanram Y, Gupta AK, Kapoor D, Nityanand S. Isolation and characterization of mesenchymal stem cells from human fetus heart. PLoS One. 2018, 13(2):e0192244. PMID: 29420637.
Gupta AK, Jadhav SH, Tripathy NK, Nityanand S. Fetal kidney cells can ameliorate ischemic acute renal failure in rats through their anti-inflammatory, anti-apoptotic and anti-oxidative effects. PLoS One. 2015, 10(6): e0131057. PMID: 26086475.
Gupta AK, Jadhav SH, Tripathy NK, Nityanand S. Fetal kidney stem cells ameliorate cisplatin induced acute renal failure and promote renal angiogenesis. World J Stem Cells, 2015 May 26, 7(4): 776-788. PMID: 26029348.
Reviewer for PLoS One
American Society of Nephrology, 2017-Present
International Society for Stem Cell Research, 2015-Present
International Society of Nephrology, 2013- Present