Anyonya Guntur, PhD

Faculty Scientist I

Education

BS: Chemistry, Microbiology & Botany, Osmania University, Hyderabad, India
MS: Biotechnology, University of Texas at San Antonio
PhD: Biochemistry, University of Texas Health Science Center at San Antonio, Texas

(Left to Right) Josh Passarelli, Li Tian, Dr. Guntur, and Victoria Van Berlo

A complete list of publications can be found on My NCBI

Beauchemin M, Geguchadze R, Guntur AR, Nevola K, Le PT, Barlow D, Rue M, Vary CPH, Lary CW, Motyl KJ, Houseknecht KL. Exploring mechanisms of increased cardiovascular disease risk with antipsychotic medications: Risperidone alters the cardiac proteomic signature in mice. Pharmacol Res. 2019 Dec 21;:104589. doi: 10.1016/j.phrs.2019.104589. [Epub ahead of print] PubMed PMID: 31874253.

Busse E, Simkin J, Marrero L, Stewart K, Brunauer R, Muneoka K, Guntur A, Lacey M, Sammarco M. Sirtuin 3 deficiency does not impede digit regeneration in mice. Sci Rep. 2019 Nov 11;9(1):16491. doi: 10.1038/s41598-019-52921-z. PubMed PMID: 31712596; PubMed Central PMCID: PMC6848098.

Le PT, Bornstein SA, Motyl KJ, Tian L, Stubblefield JJ, Hong HK, Takahashi JS, Green CB, Rosen CJ, Guntur AR. A novel mouse model overexpressing Nocturnin results in decreased fat mass in male mice. J Cell Physiol. 2019 Nov;234(11):20228-20239. doi: 10.1002/jcp.28623. Epub 2019 Apr 5. PubMed PMID: 30953371; PubMed Central PMCID: PMC6660355.

Gurumurthy CB, O’Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D’Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G. Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol. 2019 Aug 26;20(1):171. doi: 10.1186/s13059-019-1776-2. PubMed PMID: 31446895; PubMed Central PMCID: PMC6709553.

Fujiwara M, Tian L, Le PT, DeMambro VE, Becker KA, Rosen CJ, Guntur AR. The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice. J Biol Chem. 2019 Aug 23;294(34):12683-12694. doi: 10.1074/jbc.RA119.008630. Epub 2019 Jul 2. PubMed PMID: 31266807; PubMed Central PMCID: PMC6709636.

Maridas DE, Rendina-Ruedy E, Helderman RC, DeMambro VE, Daniel Brooks, Guntur AR, Lanske B, Bouxsein ML, Rosen CJ. Progenitor Recruitment and Adipogenic Lipolysis Contribute to the Anabolic Actions of Parathyroid Hormone on the Skeleton. 2018 FASEB Journal

Su S, Guntur AR, Nguyen DC, Fakory SS, Doucette CC, Leech C, Lotana H, Kelley M, Kohli J, Martino J, Sims-Lucas S, Liaw L, Vary C, Rosen CJ, Brown AC. A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome. Cell Rep. 2018 Dec 11;25(11):3215-3228.e9. doi: 10.1016/j.celrep.2018.11.037. PubMed PMID: 30540952; PubMed Central PMCID: PMC6375695.

Guntur AR, Gerencser AA, Le PT, DeMambro VE, Mookerjee SA, Clemmons DE, Brand, MD, and Rosen CJ. Osteoblast like MC3T3-E1 cells prefer glycolysis for ATP production but adipocyte like 3T3-L1 cells prefer oxidative phosphorylation. 2018 Journal of bone and mineral research.

Carvalho AL, DeMambro VE, Guntur AR, Le P, Nagano K, Baron R, de Paula, FJA, and Motyl KJ. High Fat Diet Attenuates Hyperglycemia, Body Composition Changes, and Bone Loss in Male Streptozotocin-Induced Type 1 Diabetic Mice. Journal of cellular physiology 2018 Feb;233(2):1585-1600.

Motyl KJ, Guntur AR Carvalho AL and Rosen CJ. Energy Metabolism of Bone. Toxicologic Pathology 2017 Oct;45(7):887-893.

Rendina-Ruedy E, Guntur AR, and Rosen CJ. Intracellular Lipid Droplets Support Osteoblast Function. Adipocyte 2017 Jul 3;6(3):250-258.

Lee W.-C, Guntur AR, Long F, and Rosen CJ. (2017) Energy Metabolism of the Osteoblast: Implications for Osteoporosis. Endocrine Reviews 38, 255-266

DeMambro VE, Le PT, Guntur AR, Maridas DE, Canalis E, Nagano K, Baron R, Clemmons DR, Rosen CJ. Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss. Endocrinology. 2015;156(11):4129-40. Epub 2015/08/01. doi: 10.1210/en.2014-1452. PubMed PMID: 26230658; PMCID: Pmc4606757.

Appointments

Assistant Professor, Department of Medicine, Tufts University School of Medicine, Boston, MA
Member, Graduate Faculty, Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME

Awards
2009    Best oral presentation, Biochemistry annual retreat, University of Texas Health Science Center at San Antonio.
2009    Young Investigator Award, American Society for Bone and Mineral Research.
2015     NIAMS R03
2016     Endo Outstanding abstract travel award
2016     Invited ‘Knockout round’ talk at ENDO
2017     John Haddad Young Investigator Award (AIMM)
2017     Harold Frost Young investigator award (ASBMR)

Member
American Society for Bone and Mineral Research
Endocrine Society

Peer Reviewer for the Following Journals:

  • Mechanisms of Aging and Development
  • International Journal of Oral Science
  • Stem cell research
  • Bone
  • International Immunopharmacology
  • Endocrinology
  • Journal of bone and mineral research
  • PNAS

Currently Funded Projects

  • P20GM121301:  Liaw Lucy PhD (PI) NIH/NIGM (COBRE in Mesenchymal and neural networks) Role: PI Guntur Anyonya, Title: The essential role for mitophagy in osteoblast differentiation

Completed Funded Projects

  • P20GM121301:  Liaw Lucy PhD (PI) NIH/NIGM (COBRE in Mesenchymal and neural networks) Pilot Project: Sep 2017-18:   Role: PI Guntur Anyonya, Title: Mitochondrial dysfunction as a mechanism of bone loss in T1D 
  • P30GM106391:  Robert Friesel PhD (PI) NIH/NIGM (COBRE in Stem and Progenitor Cell Biology) Pilot Project: Aug 2017-18:  Role: PI Guntur Anyonya, Title:  Modelling osteoporosis with patient derived iPSCs
  • RO3 3year grant from NIAMS: Role of MITONEET in regulating osteoblast bioenergetics and catabolism. 2016 -2019  Role: PI Guntur Anyonya