Aldona Karaczyn, PhD

Staff Scientist


MSc: Medical Analytics (Faculty of Pharmacy– Wroclaw Medical University, Wroclaw, Poland)
PhD: Bioinorganic and Biomedical Chemistry (Faculty of Chemistry, University of Wroclaw, Wroclaw, Poland)

Rochira JA, Matluk N, Adams TL, Karaczyn AA, Oxburgh L, Hess ST, Verdi JM. A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-kappaB activation and apoptosis in P19 cells. PLoS One. 2011; v 6(7):e20659. PMCID: PMC3138748.

Karaczyn A, Bani-Yaghoub M, Tremblay R, Kubu C, Cowling R, Adams T, Prudosky I, Spicer D, Friesel R , Vary C, Verdi J. Two novel human NUMB isoforms provide a potential link between development and cancer. Neural Dev. 2010; 5:31. PMCID: PMC3009962.

Matluk N, Rochira JA, Karaczyn A, Adams T, Verdi JM. A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. BMC Biol. 2010;8:7. PMCID: PMC2829509.

Nikopoulos GN, Martins JF, Adams TL, Karaczyn A, Adams D, Vary C, Oxburgh L, Verdi JM. NRAGE: a potential rheostat during branching morphogenesis. Mech Dev. 2009;126(56):337-49. PMC2702142.

Karaczyn AA, Cheng RY, Buzard GS, Hartley J, Esposito D, Kasprzak KS. Truncation of histone H2A’s C-terminal tail, as is typical for Ni(II)-assisted specific peptide bond hydrolysis, has gene expression altering effects. Ann Clin Lab Sci. 2009;39(3):251-62. PMCID: PMC2772094.

Salnikow K, Aprelikova O, Ivanov S, Tackett S, Kaczmarek M, Karaczyn A, Yee H, Kasprzak KS, Niederhuber J. Regulation of hypoxia-inducible genes by ETS1 transcription factor. Carcinogenesis. 2008;29(8):1493-9. PMCID: PMC2516492.

Karaczyn AA, Golebiowski F, Kasprzak KS. Ni(II) affects ubiquitination of core histones H2B and H2A. Exp Cell Res. 2006;312(17):3252-9.

Karaczyn A, Ivanov S, Reynolds M, Zhitkovich A, Kasprzak KS, Salnikow K. Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. J Cell Biochem. 2006;97(5):1025-35.

Kowara R, Karaczyn A, Cheng RY, Salnikow K, Kasprzak KS. Microarray analysis of altered gene expression in murine fibroblasts transformed by nickel(II) to nickel(II)-resistant malignant phenotype. Toxicol Appl Pharmacol. 2005;205(1):1-10.

Karaczyn AA, Golebiowski F, Kasprzak KS. Truncation, deamidation, and oxidation of histone H2B in cells cultured with nickel(II). Chem Res Toxicol. 2005;18(12):1934-42.

Kasprzak KS, Bal W, Karaczyn AA. The role of chromatin damage in nickel-induced carcinogenesis. A review of recent developments. J Environ Monit. 2003;5(2):183-7.