Our laboratory is interested in determining the role of CTHRC1 induced during tissue repair such as after myocardial infarction. In addition, we seek to understand the significance of circulating CTHRC1 in athletic performance and inflammation.
Pyagay P, Heroult M, Wang Q, Lehnert W, Belden J, Liaw L, Friesel RE, Lindner V. Collagen Triple Helix Repeat Containing 1 (Cthrc1), a novel secreted protein in injured and diseased arteries inhibits collagen expression and promotes cell migration. Circ.Res. 96: 281-268 (2005)
Stohn JP, Perreault NG, Wang Q, Liaw L, Lindner V. Cthrc1, a novel circulating hormone regulating metabolism. PLoS One 2012;7(10):e47142.
Stohn JP, Wang Q, Siviski ME, Kennedy K, Jin Y-R, Kacer D, DeMambro V, Liaw L, Vary CP, Rosen CJ, Prudovsky I, Lindner V. Cthrc1 Controls Adipose Tissue Formation, Body Composition, and Physical Activity. Obesity 2015; 23:1633-1642.
Jin Y-R, Stohn JP, Wang Q, Nagano K, Baron R, Bouxsein ML, Rosen CJ, Adarichev VA, and Lindner V. Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1. Bone 2017; 97:153-167.